Category: Health News

Gb Sciences’ anxiety formulations were previously identified using the company’s AI-driven PhAROS™ platform, and they have now been evaluated using preclinical zebrafish models of stress at the National Research Council of Canada.

GB Sciences

LAS VEGAS – October 24, 2022 – (Newswire.com)

Gb Sciences, Inc. (“GbS”; OTCQB:GBLX), a leading plant-inspired research and biopharmaceutical drug development company, has received positive preclinical results in an interim report from its study using preclinical zebrafish models of stress at the National Research Council of Canada (NRC). GbS’ proprietary anxiety formulations have achieved a statistically significant reduction of stress in this preclinical study. The NRC is testing GbS’ proprietary, psychotropic plant-based formulas for the treatment of depression and anxiety. GbS has leveraged its patent-pending PhAROS™ (Phytomedical Analytics for Research Optimization at Scale) platform to identify these combinations of plant compounds for novel drug candidates. These are the company’s first non-cannabis formulations to advance in preclinical studies.

“We have achieved an important milestone in the development of our novel, kava-inspired anxiety formulations. Not only did some of our formulations achieve statistical significance in the animal model, but these minimum essential mixtures also demonstrated synergy by significantly outperforming the individual active ingredients within our minimum essential mixture formulations,” said Dr. Andrea Small-Howard, Gb Sciences’ President and Chief Science Officer. “This preclinical data also confirms that our PhAROS™ platform was capable of yielding concrete, potentially effective, plant-inspired combination drugs.”

For these novel psychotropic drug candidates, the Gb Sciences research team used the PhAROS™ platform to identify new ingredients to improve upon an initial formulation for anxiety based on traditional medicine. The original plant mixture was derived from the kava plant, but some elements of kava are thought to cause liver toxicity. PhAROS™ identified ingredients from the Piper plant family as a substitute for the functionality of the ingredients in question without the potentially adverse safety profiles of those original ingredients. The Piper plant family includes pepper plants that are used worldwide in traditional medicines.

The PhAROS^TM platform is a revolutionary, AI-driven science gateway and virtual research environment for drug discovery. With its data analytics and machine learning capabilities, PhAROS™ allows Gb Sciences to greatly reduce the time and money required to bring novel, plant-inspired formulations to market. PhAROS™ represents a breakthrough combination of data sciences and traditional plant-based medicines. 

To learn more about Gb Sciences, visit www.gbsciences.com.

About Gb Sciences and GbS Global Biopharma

Gb Sciences, Inc. is a plant-inspired, biopharmaceutical research and development company creating patented, disease-targeted formulations of cannabis- and other plant-inspired therapeutic mixtures for the prescription drug market through its Canadian subsidiary, GbS Global Biopharma, Inc. The ‘plant-inspired’ active ingredients in its therapeutic mixtures are synthetic homologues identical to the original plant compounds but produced under current Good Manufacturing Practices. Gb Sciences’ intellectual property portfolio contains six issued U.S. and three issued foreign patents, as well as 17 U.S. and 51 foreign patent-pending applications. In its drug development pipeline, Gb Sciences has five preclinical phase product development programs. Gb Sciences’ lead program for Parkinson’s disease is being prepared for a first-in-human clinical trial. Gb Sciences’ formulations for chronic pain, anxiety, and depression are currently in preclinical animal studies with researchers at the National Research Council of Canada (NRC). The company also received positive preclinical proof-of-concept data supporting its complex mixtures for the treatment of Cytokine Release Syndrome, and its lead candidates will be optimized based on late-stage preclinical studies at Michigan State University. Gb Sciences’ productive research and development network includes distinguished universities, hospitals, and Contract Research Organizations. To learn more, visit www.gbsciences.com. 

Forward-Looking Statements

This press release may contain statements relating to future results or events, which are forward-looking statements. Words such as “expects,” “intends,” “plans,” “may,” “could,” “should,” “anticipates,” “likely,” “believes” and words of similar import may identify forward-looking statements. These statements are not historical facts, but instead represent only the Company’s belief regarding future events, many of which, by their nature, are inherently uncertain and outside of the Company’s control. It is possible that the Company’s actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements. Further, information concerning the Company and its business, including factors that potentially could materially affect the Company’s business and financial and other results, are contained in the Company’s filings with the Securities and Exchange Commission, available at www.sec.gov. All forward-looking statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter become aware.

Media Contact

Alexis Quintal

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Gb Sciences’ Plant-based Formulations Designed to Treat Anxiety Achieve Statistical Significance in Animal Study

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Recognition Reinforces Company’s Commitment to Quality Management Standards

MOUNT VERNON, N.Y. – October 21, 2022 – (Newswire.com)

Bona Fide Masks Corp.  (www.bonafidemasks.com), part of the Ball Chain Manufacturing Co., Inc. (Ball Chain) family of companies out of Mount Vernon, New York, is proud to announce that it has received ISO 9001:2015 certification from the International Organization for Standardization (ISO), an organization which has established a coordinated system of quality management standards.

After a rigorous evaluation process, Bona Fide Masks® is the first mask distributor to receive this industry distinction. The ISO vetting process includes all aspects of the company’s business, including purchasing, supply chain integrity, logistics, delivery, infrastructure, testing, human resources, finance, and accounting. By seeking and earning IS0 9001 certification, Bona Fide Masks has underscored its unwavering commitment to its customers and its business partners, meeting and exceeding high-level international standards. The company remains committed to delivering premier products, using safe and sustainable processes. Operating under the ISO 9001:2015 standard helps ensure that Bona Fide Masks’ customers receive authentic, high-quality products that meet or exceed strict standards.

“We worked closely with the ISO auditors during their thorough evaluation process, which resulted in the certification. As a mask distributor operating in a confusing marketplace, we are proud to be the trusted source for masks. We continue to invest back in our company, delivering on our brand promises to provide the highest-level products under an unmatched management program.” – Chief Engineer and EVP, Val Taubner III. 

“Our ISO certification exemplifies that we have strong, clearly defined procedures in place in all our business areas to ensure that all masks that we purchase and then distribute are authentic. Our transparent, perpetual vetting model is unique in the mask industry. I want our customers to know that they can always trust us, and we will always conduct our business ethically. This accreditation solidifies our brand pledge and builds on our promises. We will continue to raise standards and expectations for our industry.” – President, Bill Taubner.

Now certified under the ISO 9001:2015 standard, Bona Fide Masks is proud to join the one million+ companies and organizations, in over 170 countries, with ISO certification.

More about ISO:

Dating to 1946, the International Organization for Standardization (ISO) is an independent, non-governmental international organization with a membership of 167 bodies. It sets forth a framework of international quality management standards for entities committed to delivering products that consistently meet customer expectations. ISO audits are performed by a qualified, independent certifying body (www.iso.org).

More about Ball Chain Manufacturing Co., Inc. and Bona Fide Masks Corp.: 

The current owners’ great-grandfather and grandfather started Ball Chain Manufacturing Co., Inc. (Ball Chain) in a small garage behind their home in the Bronx, NY. The company has been family-owned and operated since 1938. Ball Chain is now the world’s largest manufacturer of ball chains (www.ballchain.com), seen on military dog tags, ceiling fans, handbags and light pulls, among many other goods. The company manufactures more than 3 million feet of product per week at its Mount Vernon, New York factory (all ball chains are made in the USA). Ball Chain is the exclusive supplier to the U.S. military for the iconic dog tag ID necklace worn by U.S. servicemen and women, and the company takes tremendous pride in everything it does.   

Originally a division of Ball Chain, Bona Fide Masks Corp. handles warehousing and distribution with the utmost focus, systematically employing proven, regimented processes and protocols, as supply chain security and transparency are its highest priorities. In this regard, Bona Fide Masks is proud to issue statements of authenticity, providing further confidence to its customers and reinforcing its commitment to supply chain integrity.

Contact Information:

Cristina Chianese

VP of Marketing & Strategy

cristina@ballchain.com

Bill Taubner

President

bill@ballchain.com

914.664.7500

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Bona Fide Masks ISO 9001 Certification

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Bona Fide Masks Corp. Awarded ISO 9001 Certification, Becoming First Mask Distributor to Achieve Designation